Large deviations for two scale chemical kinetic processes

We formulate the large deviations for a class of two scale chemical kinetic processes motivated from biological applications. The result is successfully applied to treat a genetic switching model with positive feedbacks. The corresponding Hamiltonian is convex with respect to the momentum variable as a by-product of the large deviation theory. This property ensures its superiority in the rare event simulations compared with the result obtained by formal WKB asymptotics. The result is of general interest to understand the large deviations for multiscale problems

Two-scale large deviations for chemical reaction kinetics through second quantization path integral

Motivated by the study of rare events for a typical genetic switching model in systems biology, in this paper we aim to establish the general two-scale large deviations for chemical reaction systems. We build a formal approach to explicitly obtain the large deviation rate functionals for the considered two-scale processes based upon the second-quantization path integral technique. We get three important types of large deviation results when the underlying two times scales are in three different regimes. This is realized by singular perturbation analysis to the rate functionals obtained by path integral. We find that the three regimes possess the same deterministic mean-field limit but completely different chemical Langevin approximations. The obtained results are natural extensions of the classical large volume limit for chemical reactions. We also discuss its implication on the single-molecule Michaelis-Menten kinetics. Our framework and results can be applied to understand general multi-scale systems including diffusion processes

Entanglement renormalization and integral geometry

We revisit the applications of integral geometry in AdS$_3$ and argue that the metric of the kinematic space can be realized as the entanglement contour, which is defined as the additive entanglement density. From the renormalization of the entanglement contour, we can holographically understand the operations of disentangler and isometry in multi-scale entanglement renormalization ansatz. Furthermore, a renormalization group equation of the long-distance entanglement contour is then derived. We then generalize this integral geometric construction to higher dimensions and in particular demonstrate how it works in bulk space of homogeneity and isotropy.Comment: 40 pages, 7 figures. v2: discussions on the general measure added, typos fixed; v3: sections reorganized, various points clarified, to appear in JHE